According to Dr. Susan Ott, a specialist in Metabolic Bone Disease at the University of Washington, "Many people believe that these drugs are bone-builders, but the evidence shows they are actually bone-hardeners." This class of drugs, known as bisphosphonates, have been linked to over 40 adverse health effects. Risks associated with these drugs are most pronounced for long-term use, defined as ten years or more.[7] Although it is produced naturally in the body, estradiol as an estrogen replacement may have cardiotoxic and carcinogenic properties when levels are too high.[8] Supplementation in otherwise healthy women can dangerously inflate these levels, as can any non-related health condition that causes detoxification pathways to work sub-optimally. Genistein: Nature's Superior Prescription Nature has supplied humankind's healthiest medicine cabinet since long before the American Medical Association (AMA) decided that only pharmaceutical drugs can heal people. And when it comes to maintaining healthy bones into our senior years, there is a plant-based solution that puts HRT and bone drugs to shame: it's called genistein. An isoflavone, or bioactive flavonoid found primarily in beans such as soy, fava, garbanzos, and coffee, genistein is a phytoestrogen due to its similarity in structure to human estrogen. Eating a diet high in phytoestrogens has been attributed with alleviating symptoms of menopause and conveying preventative or therapeutic effects against cancer, atherosclerosis, and osteoporosis.[9] Of all isoflavones, genistein possesses the strongest estrogenic activity.[10] The powerful effects of genistein on bone health were illustrated in a landmark study published in the British Journal of Pharmacology in 2008. Using an animal model of menopausal osteoporosis, researchers concluded that prescription bone-density drugs alendronate (Fosamax), raloxifene (Evista), and estradiol (estrogen, E2), are all inferior to the phytoestrogen genistein in preserving bone mineral density (quantity) and strength (quality). What makes this finding so groundbreaking are the comparative benefits-versus-risks of these four different forms of treatment for bone-loss. Genistein is a plant derivative that acts naturally and holistically on the body, strengthening what is weak without causing damage to other parts of the body. In contrast, all three prescription drugs are made from biologically-foreign chemicals (xenobiotics) that can have profound, unintended adverse health effects like "frozen" and crumbling bones, among other horrific outcomes. Genistein has been extensively researched for its potential therapeutic role in osteoporosis prevention and treatment, as well as hundreds of other health conditions. And while phytoestrogens have come under scrutiny as part of the broader reevaluation of HRT, genistein's natural biocompatibility appears to have a more positive effect on the body than synthetic hormones in cases when endogenously-produced estrogen levels fail to meet the body's optimal requirements. Genistein's highly selective activity is capable of binding and stimulating bone estrogen receptor sites resulting in increased strength/density for bones. Genistein has much weaker estrogenic activity compared to estradiol, yet it is capable of binding to the same estrogen receptors for a much longer duration, which may result in significant, longer-term positive effects without the risks associated with high estrogen levels. This process of binding with estrogen receptors provides an added layer of protection against cancer by preventing the estrogen from binding and initiating cancer growth. In addition to estrogenic and anti-cancer activity, genistein is a powerful antioxidant. Consuming genistein regularly in the diet can remove dangerous free radicals from the bloodstream, effectively slowing down the aging process. Other studies show it is highly effective at lowering blood pressure and improving the quality of arterial walls, validating genistein's cardioprotective properties.[11] Eat Your Way to Bone Health The evidence speaks loudly that more awareness must be given to natural, food-based alternatives to pharmaceutical drugs, particularly when a substance has mountains of scientific data proving efficacy. Fermented soy--the most potent form of food-based genistein-- has a long-standing history as a healing food, spanning many centuries and numerous cultures. Studies have shown that genistein is primarily absorbed in the GI tract, where it is extensively metabolized throughout the body. This makes food an ideal way to supplement this vital nutrient. Natto, a traditional Japanese food made by cooking fermented soybeans, has long been believed to destroy blood clots and improve blood glow, among other benefits. Tempeh, a fermented soybean cake with a firm texture and nutty taste, is a popular protein source for vegans and vegetarians, as well as staple in the diets of many Asian countries. Miso, a fermented soybean paste used to make delicious miso soup, is an inexpensive and easy way to integrate genistein into the daily diet. As eating well becomes more popular and even fashionable, products such as fermented soy drinks and snack foods have become available at select markets and specialty stores. Asian markets are a great place to find a large variety of fermented soy foods, however it should be noted that these labels may not indicate if the product is made from GMO-soybeans. With more than 90% of all soybeans in the world now a genetically-modified version of the crop,[12] it is vital to source organic, non-GMO soy and genistein products. Caution should be exercised when purchasing supplements for this same reason, and because genistein's poor solubility "may prevent absorption of larger doses without proper formulations."[13] It is possible to eat your way to bone health and hormonal balance. Both your body and your bones deserve nothing less! Read more at: GreenMedInfo.com
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